Celestamine belongs to the steroid family drugs and it contains Betamethasone and dexchlorpheniramine maleate as active ingredients. Celestamine (Betamethasone/ dexchlorpheniramine) is commonly used to treat hypersensitivity or allergic reactions and inflammatory conditions.

Indications / Diseases where Celestamine is used:

  • Perennial allergic rhinitis
  • Severe bronchial asthma
  • Serum sickness
  • Hay fever (pollenosis)
  • Drug reactions
  • Atopic dermatitis (eczema)
  • Contact dermatitis
  • Inflammatory ocular disorders
    • Iridocyclitis
    • Uveitis
    • Keratitis
    • Conjunctivitis
    • Non-granulomatous iritis
    • Chorioretinitis and
    • Choroiditis

Celestamine Dosage

Dose of Celestamine depends on the patient’s response to the drug and the severity of the illness.

  • In the case, the conditions are better; the dosage should be reduced little by little until it is reduced to a minimum.
  • After reaching the lowest dose, it should be suspended slowly.
  • For people older than 12 years, an initial dose of 1 or 2 tablets (1 or 2 tablespoons) is prescribed for four times a day.
  • It is best to take the dose after a filling meal or at bedtime.
  • Do not increase the dose of Celestamine Ns in more than eight tablets or 8 tablespoons in the case of Celestamine Ns syrup.
  • For children between 6 and 12 years, a dose of ½ tablet (1/2 tablespoon) should be administered three times a day. The dose should not exceed more than 4 tablets or 4 tablespoons in the case of syrup.
  • For children between 2 and 6 years old, a dose of ¼ or ½ tablespoon should be administered three times a day. The general dosage should not be more than two tablespoons.

Side effects of Celestamine 

  • Nausea and vomiting are usual side effects. 
  • Increased sweating
  • It can produce a sedative effects in which a person is always sleepy or drowsy.
  • In some people, an alteration in electrolyte and fluid balance is also seen.
  • Muscle problems such as loss of muscle mass, weakness of muscle  and rupture of the tendon are common. 
  • Sometimes depression, mood swings and some other psychological problems are also seen in Celestamine users.
  • In cases of women, menstrual irregularity is also common
  • Some people also complain of vertigo and headache.
  • There are also complains  distension of the abdomen.
  • There are also cases of Peptic ulcer, constipation and irritable bowel syndrome can occur.
  • Delayed wound healing is also seen.
  • Skin discoloration, thinning of the skin are some of the common complains of Celestamine.


Contraindications :
  • Never use this drug in a patient who is having any fungal infection in the body.
  • Should not be used in newborn and premature infants.
  • Using Celestamine in patients who have shown hypersensitivity to Betamethasone or Dexchlorphenamine Maleate  or any chemical compounds similar to Celestamine should be avoided. 


Drug and Food Interactions of Celestamine

Celestamine may interact with several other drugs  and foods that can increase the risk of side effects. To avoid the  harmful drug interactions, yo should always inform your doctor about the drugs that you are taking currently. 

Medications that may cause drug interactions with Celestamine are,

  • Cardiac glycosides enhance arrhythmias or digitalis toxicity.
  • Phenobarbital, phenytoin, rifampicin, ephedrine enhance the metabolism of Celestamine (Betamethasone/ dexchlorpheniramine).
  • Coumarins, aspirin, NSAIDs, antidiabetic drugs.

Foods or alcohol will also interact with Celestamine and increase the risk for serious side effects. 

Some diseases or health conditions can alter the way the drug works. It is important to inform your doctor about the diseases you have especially if you have liver or kidney disease, diabetes, tuberculosis, glaucoma, osteoporosis, cataract, thyroid diseases, stomach problems (ulcer, bleeding), diverticulitis, ulcerative colitis, Chest congestion, heart problems, depression, mental sickness, high blood pressure etc


  • How to store Celestamine?

Celestamine should be stored at room temperature away from direct light and moisture. To prevent damage of the drug, it should not be stored in the bathroom or the freezer. It is important to check the product package for instructions on storage, or ask your pharmacist as there are different brands of Celestamine.

For safety, keep all medicines away from children and pets.

Do not flush Celestamine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard the drug when it is expired or no longer needed. Seek advice from the pharmacist for more details on how to discard the drug safely.

  • How should I take Celestamine® (Betamethasone/ dexchlorpheniramine?

It comes as a tablet to take by mouth, should be taken with food, after meals or at bedtime.

  • Is it safe to use Celestamine during pregnancy or breastfeeding?

Celestamine is not safe to take if you are breastfeeding or planning to start breastfeeding. Celestamine is a corticosteroid that  can harm the fetus or an infant. This drug can also interrupt the normal growth of a newborn baby. Always consult a doctor before using Celestamine if you are a breastfeeding mother. 



Additional biochemical information about Celestamine

  • Chemical Names:
    • Celestamine
    • Betamethasone / dexchlorpheniramine
    • Betamethasone / dexchlorpheniramine maleate
    • Betamethasone mixture with dexchlorpheniramine maleate
    • SCHEMBL3361523
    • 62682-62-6
  • Molecular Formula:
  • Molecular Weight: 783.331 g/mol
Celestamine - 2D Structure
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