Madecassol – Uses, Doses and Side Effects

Madecassol

It contains Centella Asiatica Exract as an active ingredient, which in turn is used as an ointment, decreasing inflammation and blood pressure in the veins.
Madecassol is used for minor injuries and other conditions. It can also be used for purposes not mentioned in this medication guide.

Uses

  • Minor injuries
  • Psoriasis
  • Varicose veins
  • Chronic venous insufficiency.
madecassol

Side effects

These are possible side effects of Madecassol and Consult your doctor if you notice any of the following side effects, especially if they do not go away.

  • Skin allergy
  • Headache.
  • Stomach ache.
  • Sickness.
  • Dizziness
  • Drowsiness.

It can also cause side effects which are not mentioned here. If you notice any side effect after using this medication, contact your doctor for medical advice.

You can also report side effects to your local food and drug administration authority.

Precautions
Before using Madecassol, inform your doctor about your current list of medications:

  • Over-the-counter products (eg, vitamins, herbal supplements, etc.)
  • Allergies
  • Pre-existing diseases.
  • Current health conditions (for example, pregnancy, upcoming surgery, etc.).

Some health conditions may make you more susceptible to the side effects of the medication.

How to use Madecassol
Take as directed by your doctor or follow the address printed on the product packaging. The dose is based on your condition. Tell your doctor if your condition persists or worsens.

The important points of advice are listed below:

  1. Do not take by mouth. Consult your doctor before using this medicine on open wounds, dry, chapped, irritated or sunburned skin.
  2. Wash your hands before and after applying it. Clean and dry the area of the skin to be treated.
  3. Do not wash the treated area after applying Madecassol immediately. Also avoid using other products in the treated area unless directed by your doctor.
  4. Applying an excessive amount can result in pilling. Use a thinner coat or a lesser amount of medication to prevent the formation of pellets.
  5. Avoid getting this medication in your eyes, nose or mouth.

 

Research articles about side effects of Madecassol.

The electron microscopic study of effects of Centella asiatica (Madecassol) on the burn lesions – Research Gate

  • ABSTRACT
    In this study the mice with experimental skin burn were divided into four groups and Madecassol were injected to each of them once a day. First group was sacrificed at the end of the first day, the second after 48 hours, the third after 72 hours and the fourth after 11 days. Routine electron microscopic follow up procedures was used for the skin samples taken from each group. The structural changes caused by the application of Madecassol was examined under electron microscope. No significant difference was found between the 24, 48 and 72 hours Madecassol injected groups and the control group. However the regeneration of skin was faster in the group which was injected Madecassol for 11 days. Consequently, it was observed that Madecassol caused the formation of a thin and a smooth scar and also accelerated the epithelisation.

Contact dermatitis due to madecassol.

  • AUTHOR(S): Eun, H. C.; Lee, A. Y. 
  • YEAR: 1985 CITATION: Contact Dermatitis, 13(5), 310-313 [English]
  • FDA #: F09265 
  • ABSTRACT: Case Reports: Madecassol is an extract of Centella asiatica, a member of the Umbelliferae family. It contains madecassic acid, asiatic acid and asiaticoside. It has been used as a wound healing agent and for the prevention of cicatrization. We report contact dermatitis due to Madecassol and a control study with its individual ingredients. Case 1: A 33-year-old female had applied Madecassol ointment on a keloid which occurred 10 years ago. She noted erythema with itching at the site 10 days after application. On examination, mild eczematous lesions were observed on the keloid area. She was patch tested with the Hollister-Stier standard battery, a vehicle series, Madecassol (as is) and TECA (titrated extract of Centela asiatica) 10% and 1%. She showed a ++ positive reaction only to Madecassol. Case 2: A 23-year-old female had applied Madecassol ointment for the prevention of hypertrophic scarring on the donor site of her skin graft. Itchy oozing erythematous lesions appeared on the graft site a few weeks after application. She was patch tested with the Hollister-Stier standard battery, various antiseptics used, Madecassol (as is) and its individual ingredients. She showed positive reactions to Madecassol, 10% TECA (titrated extract of Centella asiatica), propylene glycol (20%, 30%, 40%, and 50%) and geranium oil 20%. Case 3: A 26-year-old female had applied Madecassol ointment on her skin graft area as in Case 2. An erythematous papular eruption with itching was observed on her graft area 2-3 weeks after application. She showed a strong positive reaction to Madecassol only on patch testing. Case 4: An 18-year-old female had applied Madecassol ointment on a burn scar. 4 days later, itching and erythema lesions were observed at the site. She showed positive reactions to Madecassol, 10% TECA and propylene glycol (5%, 10%, 20%, 30%, 40% and 50%). Control Study and the Results: 63 normal adults were patch tested with Madecassol (as is), propylene glycol of different concentrations, TECA, asiaticoside and free genin (asiatic acid + madecassic acid), which are the components of Madecassol. 12.7% positive reactions were observed to Madecassol , and 9.5% to 1.6% reactions to propylene glycol according to the concentrations (cases with + reaction, ICDRG criteria). The active ingredients of Madecassol such as TECA, asiaticoside and free genin showed positive reactions in several normal controls, which suggested irritant reactions.

Contact dermatitis due to Madecassol – PubMed
Eun HC, Lee AY.
Abstract
Madecassol is an extract of Centella asiatica, a member of the Umbelliferae family. It contains madecassic acid, asiatic acid and asiaticoside. It has been used as a wound healing agent and for the prevention of cicatrization. We report contact dermatitis due to Madecassol and a control study with its individual ingredients.

PMID: 2936544

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